Controlled studies have been limited to 12 months of pantoprazole therapy. All material copyright MediResource Inc. 1996 – 2021. You should take antacids exactly as directed by your doctor, or according to the manufacturer's directions. If you use pantoprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Safety and efficacy beyond 16 weeks of therapy have not been established. PPI interactions can also happen with food and drink. Talk with your doctor about ways to keep your bones healthy, especially if you are an adult over 50. If you are also taking sucralfate, take pantoprazole at least 30 minutes before sucralfate. The side effects listed below are not experienced by everyone who takes this medication. Side effects can be mild or severe, temporary or permanent. What will it do for me? Pantoprazole is taken by mouth (oral) or given as an infusion into a vein (injection). Depending on your specific circumstances, your doctor may want you to: An interaction between two medications does not always mean that you must stop taking one of them. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. you are allergic to pantoprazole or similar medicines (lansoprazole, omeprazole, Nexium, Prevacid, Prilosec, and others). Your doctor may do blood tests periodically to monitor the levels of these electrolytes in your blood while you are taking this medication. At least 20 of these drugs can cause a severe reaction if taken with certain PPIs. Version: 21.01. omeprazole, amoxicillin, famotidine, metronidazole, Nexium, ranitidine, Protonix, Pepcid, Prilosec, sucralfate. Children: The safety and effectiveness of using this medication has not been established for children. Some may interact with pantoprazole, especially: This list is not complete. Your pharmacist may be able to advise you on managing side effects. To help you remember, take it at the same time each day. If Zoloft doesn’t work as quick as you were expecting, below are some potential reasons as to why it might take a longer duration to “kick in.” Possible reasons as to why Zoloft may take a while to fully alleviate your symptoms include: adaptations that require weeks to occur (e.g. Pantoprazole tablets may be taken with food or on an empty stomach. Tell your doctor about all your other medicines. new or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Swallow it whole. Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. The following side effects have been reported by at least 1% of people taking this medication. Tell the doctor or laboratory staff that you are using this medicine. Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. Call your doctor for medical advice about side effects. If needed, antacids may be taken along with this medication. If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; dry mouth; numb hands, feet, or lips; or racing heartbeat, contact your doctor as soon as possible. Take pantoprazole exactly as prescribed by your doctor. Safety and efficacy beyond 16 weeks of therapy have not been established. Follow all directions on your prescription label and read all medication guides or instruction sheets. The QUADRATE Study (n=405) - Quadruple therapy: Pantoprazole is not for the immediate relief of heartburn symptoms. Many of these side effects can be managed, and some may go away on their own over time. Copyright 1996-2021 Cerner Multum, Inc. They add up to more than 1,800 different products. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete duodenal ulcer healing in up to 87% and 94% of patients after 4 weeks and 8 weeks respectively. Diarrhea may be a sign of a new infection. If you are taking any of these medications, speak with your doctor or pharmacist. What side effects are possible with this medication? It is not known whether this medicine will harm an unborn baby. Check with your doctor as soon as possible if any of the following side effects occur: Stop taking the medication and seek immediate medical attention if any of the following occur: Some people may experience side effects other than those listed. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skin conditions: Subacute cutaneous lupus erythematosus is a skin condition that may develop in certain people taking pantoprazole or other similar medications. Data sources include IBM Watson Micromedex (updated 3 May 2021), Cerner Multum™ (updated 4 May 2021), ASHP (updated 3 May 2021) and others. Take the first missed dose the morning after you remember and if you missed both doses, take the second missed dose the morning after you take the first one. These factors may affect how you should use this medication. Sabine Roman, in Clinical and Basic Neurogastroenterology and Motility, 2020. Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. Find everything you need to know about Pantoprazole (Protonix), including what it is used for, warnings, reviews, side effects, and interactions. Oral: 40 mg orally once a day, for short-term administration (up to 8 weeks); however an additional 8 weeks may be considered for patients who have not healed after the initial treatment. Doxycycline comes as a capsule, delayed-release capsule, tablet, delayed-release tablet, and suspension (liquid) to take by mouth. Swallow them whole with a glass of water in the morning either before, during, or after breakfast. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. This is not a complete list of side effects and others may occur. You may be more likely to have a broken bone while using pantoprazole long-term or more than once per day. As well, some forms of this medication may not be used for all of the conditions discussed here. Do not chew or crush the tablets. You may report side effects to FDA at 1-800-FDA-1088. This medicine may cause hypomagnesemia (low magnesium in the blood). Usual Adult Dose for Helicobacter pylori Infection: Study (n=242) - Triple therapy: If you develop a rash on areas of skin that are exposed to the sun, such as the face, arms, or shoulders, check with your doctor as soon as possible. Do not give this medication to anyone else, even if they have the same symptoms as you do. Common pantoprazole side effects may include: stomach pain, gas, nausea, vomiting, diarrhea; fever, rash, or cold symptoms (most common in children). If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. We comply with the HONcode standard for trustworthy health information. Helicobacter Pylori eradication was achieved in 82% of patients. Medically reviewed by Philip Thornton, DipPharm. Pantoprazole is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old. If you are a breast-feeding mother and are taking pantoprazole, it may affect your baby. The usual duration of this treatment is 7 days. Do not crush, break, or chew the tablet. Call your doctor right away if you have severe bone pain or are unable to walk or sit normally. Some patients have received treatment with pantoprazole for more than 2 years. you also take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey); if you had breathing problems, kidney problems, or a severe allergic reaction after taking pantoprazole in the past; or. This medication may be available under multiple brand names and/or in several different forms. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use two doses at one time. Maintenance of Healing of Erosive Esophagitis: Other medications. 40 mg orally once a day. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Usual Adult Dose for Gastroesophageal Reflux Disease: Parenteral: 40 mg once a day for 7 to 10 days, administered via intravenous infusion over a period of 15 minutes. Long-term treatment with pantoprazole may also make it harder for your body to absorb vitamin B-12, resulting in a deficiency of this vitamin. Proton pump inhibitor (PPI) interactions can occur with at least 290 medicines. Heartburn can mimic early symptoms of a heart attack. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling. Do not take a double dose to make up for a missed one. Heartburn is often confused with the first symptoms of a heart attack. 40 mg orally twice daily for 7 days, commonly in conjunction with clarithromycin and either amoxicillin or metronidazole to eradicate Helicobacter pylori, followed with 40 mg pantoprazole orally once daily until day 28. Tell your doctor if you are urinating less than usual, or if you have blood in your urine. Study (n=20 ) - Peptic Ulcer rebleeding prophylaxis after hemostasis in the Critical Care Setting: Usual Adult Dose for Zollinger-Ellison Syndrome: Parenteral: 80 mg every 12 hours, administered by 15-minute infusion. Study (n=54) If your stomach becomes upset when you take doxycycline, you may take it with food or milk. Taking pantoprazole long-term may cause you to develop stomach growths called fundic gland polyps. Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Indeed a meta-analysis on the efficacy of these OTC medications in relieving GERD … Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use pantoprazole only for the indication prescribed. Occasionally, this can cause serious infection in the digestive tract. It is important that this medication be taken exactly as prescribed by your doctor. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you experience severe watery or bloody diarrhea, fever, or abdominal pain while taking pantoprazole, contact your doctor as soon as possible. How does this medication work? Call your doctor if your symptoms do not improve or if they get worse while you are using this medicine. Breast-feeding: This medication passes into breast milk. Talk to your doctor about how to manage this condition if you develop it. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. Tell the laboratory staff that you use this medicine. The contents herein are for informational purposes only. Long term use of pantoprazole (longer than 1 year) has been associated with growth of polyps (abnormal growths) in the stomach. 80 mg IV bolus, followed by continuous infusion of 8 mg/hr for 3 days, after which therapy may be continued with an oral PPI. Doxycycline is usually taken once or twice a day. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. The recommended dose of pantoprazole to treat reflux esophagitis is 40 mg once daily in the morning for 4 to 8 weeks. 80 mg twice daily, as a bolus infusion over a period of 15 minutes, to a maximum daily dose of 240 mg, divided into three equal doses. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete gastric ulcer healing in up to 87% and 97% of patients after 4 weeks and 8 weeks respectively. This combination may lead to higher than expected amounts of methotrexate in the body and can cause serious side effects, including kidney damage, irregular heartbeat, anemia, or infection. Electrolyte balance: Long term use of pantoprazole may cause the levels of electrolytes such as potassium, calcium, and magnesium in the blood to decrease. Methotrexate interaction: Pantoprazole, like other medications in this group, may interact with methotrexate when the two medications are used at the same time. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. If you miss one or both doses of the two days in a row, once-monthly risedronate but remember more than 7 days before your next scheduled dose, you can take the missed doses. Pantoprazole is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid. These other drugs come in both brand name and generic versions. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight. osteoporosis or low bone mineral density. Triple therapy has resulted in eradication rates of greater than 95%. Pantoprazole can cause kidney problems. Severe stomach problems: If you have recurrent vomiting, difficulty swallowing, blood in the stool, significant unintentional weight loss, fatigue (anemia), or are coughing up blood, check with your doctor right away. Talk with your doctor about this risk. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed. 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